陳雲翔老師

陳雲翔老師

職稱: 
副教授
研究室名稱: 
基因治療研究室
辦公室位置: 
耕莘樓生命科學系館 LS108
連絡電話: 
(02)2905-2462
電子信箱: 
125648@mail.fju.edu.tw
學歷: 
東吳大學微生物學系學士
東吳大學微生物學碩士
英國聖安祖大學(University of St Andrews)分子病毒學博士
專長: 
病毒學
免疫學
基因治療學
研究概況: 
利用腺相關病毒載體(Adeno-associated viral vector)轉導基因到動物體內表達特定的蛋白質(抗體、神經元營養因子、胜肽…)對不同疾病模式的動物進行治療的研究。
研究方向: 
1. 藥物成癮的基因治療研究
2. 腦神經退化疾病的基因治療研究
3. 癌症標靶藥物的開發
4. 探討毒品對免疫系統及人類流感病毒感染的影響

期刊論文

  1. Tsai MT, Su YC, Chen YH, Chen CH. (2001). Lack of evidence to support the association of the human prion gene with schizophrenia. Mol Psychiatry. 6(1):74-78. (SCI)
  2. Hung CC, Chen YH, Tsai MT, Chen CH. (2001). Systematic search for mutations in the human tissue inhibitor of metalloproteinases-3 (TIMP-3) gene on chromosome 22 and association study with schizophrenia. Am J Med Genet. 105(3):275-278. (SCI)
  3. Chen YH, Tsai MT, Shaw CK, Chen CH. (2001). Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients. Am J Med Genet. 105(8):753-757. (SCI)
  4. Tsai MT, Hung CC, Tsai CY, Liu MY, Su YC, Chen YH, Hsiao KJ, Chen CH. (2002). Mutation analysis of synapsin III gene in schizophrenia. Am J Med Genet. 114(1):79-83. (SCI)
  5. Mwau M, Cebere I, Sutton J, Chikoti P, Winstone N, Wee EG-T, Beattie T, Chen YH, Dorrell L, McShane H, Schmidt C, Brooks M, Patel S, Roberts J, Conlon C, Rowland-Jones SL, Bwayo JJ, McMichael AJ, Hanke T. (2004). A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of recombinant modified vaccinia virus Ankara (MVA) vaccines in humans. J Gen Virol. 85:911-919. (SCI)
  6. Richardson C, Brennan P, Powell M, Prince S, Chen YH, Spiller OB, Rowe M. (2005). Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and alphavbeta5 integrin expression. J Gen Virol. 86:1669-1679. (SCI)
  7. Chen YH, Diassiti A, Randall RE. (2006). Genetic fusion of proteins to the SIV Tat protein enhances their immunogenicity. Vaccine. 24:708-715. (SCI)
  8. Hale BG, Jackson D, Chen YH, Lamb RA, Randall RE. (2006). Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci USA. 103:14194-14199. (SCI)
  9. Hilton L, Moganeradj K, Zhang G, Chen YH, Randall RE, McCauley JW, Goodbourn S. (2006). The NPro product of bovine viral diarrhea virus inhibits DNA binding by interferon regulatory factor 3 and targets it for proteasomal degradation. J Virol. 80:11723-11732. (SCI)
  10. Sherwood V, Burger HG, Chen YH, Sanghera S, Katafigiotis S, Randall RE, Connerton I, Mellits KH. (2007). Improved growth of enteric adenovirus type 40 in a modified cell line that can no longer respond to interferon stimulation. J Gen Virol. 88:71-76. (SCI)
  11. Young DF, Galiano MC, Lemon K, Chen YH, Andrejeva J, Duprex WP, Rima BK, Randall RE. (2009). Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist. J Gen Virol. 90:2731-2738. (SCI)
  12. Shie FS*, Chen YH*, Chen CH, Ho IK. (2011). Neuroimmune pharmacology of neurodegenerative and mental diseases. J Neuroimmune Pharmacol. 6:28-40. *: first authors with equal contributions. (SCI)
  13. Chen YH, Wu KL, Chen CH. (2012). Methamphetamine reduces human influenza A virus replication. PLoS One. 7:e48335. doi: 10.1371/journal.pone.0048335. (SCI)
  14. Chen YH, Chen CH. (2012). Neuronal auto-antibodies and psychiatric disorders. Taiwanese J Psychiatry. 26:260-270.
  15. Chen YH, Chen CH. (2013). The development of antibody-based immunotherapy for methamphetamine abuse: immunization, and virus-mediated gene transfer approaches. Curr Gene Ther. 13:39-50. (SCI)
  16. Chen YH, Huang YS, Chen CH. (2013). Increased plasma level of tumor necrosis factor a (TNF-a) in patients with narcolepsy. Sleep Med. 14:1272-1276. (SCI)
  17. Chen YH, Huang YS, Chen CH. (2013). Association analysis of HLA-DQB1 gene and narcolepsy in Han Chinese patients from Taiwan. Sleep Med. 14:1393-1397. (SCI)
  18. Chen YH*, Wu KL, Tsai HM, Chen CH. (2013). Treatment of methamphetamine abuse: an antibody-based immunotherapy approach. J Food Drug Anal. 21:s82-s86. *: corresponding author. (SCI)
  19. Hsu YC, Chen SL, Wang YJ, Chen YH, Wang DY, Chen L, Chen CH, Chen HH, Chiu IM. (2014). Signaling adaptor protein SH2B1 enhances neurite outgrowth and accelerates the maturation of human induced neurons. Stem Cells Transl Med. 3:713-722. (SCI)
  20. Chen YH*, Wu KL, Tsai MT, Chien WH, Chen ML, Wang Y. (2015). Methadone enhances human influenza A virus replication. Addict Biol. doi: 10.1111/adb.12305. *: corresponding author. (SCI)
  21. Chen YH*, Wu KJ, Wu KL, Wu KL, Tsai HM, Chen ML, Hsieh W, Lin CM, Wang Y. (2017). Recombinant adeno-associated virus-mediated expression of methamphetamine antibody attenuates methamphetamine-induced hyperactivity in mice. Scientific Reports. 7:46301.doi: 10.1038/srep46301. *: corresponding author. (SCI)
  22. Chen YH, Bae E, Chen H, Yu SJ, Harvey BK, Greig NH, Wang Y. (2019). Pifithrin-alpha reduces methamphetamine neurotoxicity in cultured dopaminergic neurons. Neurotoxicity Reserach. doi.org/10.1007/s12640-019-00050-w. (SCI)
  23. Bach S, Dossat A, Parkkinen I, Koivula P, Airavaara M, Richie CT, Chen YH, Wang Y, Harvey BK. (2019). Neuronal activation stimulates cytomegalovirus promoter-driven transgene expression. Molecular Therapy: Methods & Clinical Development. doi.org/10.1016/j.omtm.2019/06.006. (SCI)

  24. Wu KJ, Chen YH, Bae EK, Song YH, Min WK, Yu SJ. (2020). Human milk oligosaccharide 2'-fucosyllactose reduces neurodegeneration in stroke brain. Translational Stroke Res. doi.org/10.1007/s12975-019-00774z. (SCI)

  25. Chen YH*, Yu SJ, KJ, Wang YS, Tsai HM, Liao LW, Chen S, Hsieh W, Chen H, Hsu SC, Chen ML, Hoffer BJ, Wang Y. (2020). Downregulation of α-synuclein protein levels by an intracellular single-chain antibody. J Parkinson Dis. 10:573-590. doi/10.3222/JPD-191787. *: corresponding author. (SCI)

  26. Chen YH, Wang Y, Liao CH, Hsu SC. (2021). The potential of adoptive transfer of g9d2 T cells to enhance blinatumomab's antitumor activity against B-cell malignance. Scientific Reports. 11:12398. doi.org/10.1038/s41598-021-91784-1. (SCI)

  27. Chen YH, Wu KJ, Hsieh W, Harvey BK, Hoffer BJ, Wang Y, Yu SJ. (2021). Administration of AAV-alpha synuclein NAC antibody improves locomotor behavior in rats overexpressing alpha synuclein. Genes. 12:948. doi.org/10.3390/genes12060948. (SCI)

  28. Chen SC, Chen H, Yu SJ, Chen YH, Wang Y. (2021). Alleviation of methamphetamine sensitization by partially lesioning dopaminergic terminals with 6-hydroxydopamine in neulceus accumbent. Cell Transplantation. 30:1-8. doi.org/10.1177/09636897211052300. (SCI)

  29. Wu KJ, Wang YS, Hung TW, Bae EK, Chen YH, Kim CK, Yoo DW, Kim GS, Yu SJ. (2023). Herbal formula PM012 induces neroprotection in stroke brain. Plos One. doi.org/10.1371/journal.pone.0281421. (SCI)

  30. Wu KJ, Hung TW, Wang YS, Chen YH, Bae EK, Yu SJ. (2023). Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease. Scientific Reports. 13:8148. doi.org/10.1038/s41598-023-35274-6. (SCI).

  31. Chiu YS, Wu KJ, Yu SJ, Wu KL, Wang YS, Lin J, Chu CY, Chen S, Chen H, Hsu SC, Wang Y, Chen YH*. (2023). Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein. Plos One. doi.org/10.1371/journal.pone.0291927. *: corresponding author. (SCI)

 
 
 
 
 
 
 
相關連結: 
 
 
 
 
 
 
 
 
  1. Title: Influenza A virus activates PI3K signaling for efficient virus replication. Organization: Department of Life Science, Tunghai University, Taichung, Taiwan. June 10, 2009. Language: Chinese.
  2. Title: Treatment of methamphetamine abuse: an antibody-based immunotherapy approach. Organization: International Conference on Global Health: Prevention and Treatment of Substance Use Disorders and HIV. Howard Civil Service International House, Taipei, Taiwan. April 17-19, 2013. Language: English.
  3. Title: Methadone enhances influenza A virus replication both in vitro and in vivo. Organization: Center for Neuropsychiatric Research, National Health Research Institutes, Taiwan. February 27, 2014. Language: English.
  4. Title: An AAV-mediated Passive Immunization Attenuates Methamphetamine-induced Behavioral Changes in Mice. Organization: 2014 NHRI Research Day, National Health Research Institute, Taiwan. March 17 -18, 2014. Language: English.
  5. Title: Methamphetamine reduces human influenza A virus replication. Organization: Department of Life Science, Fu Jen Catholic University, Taiwan. September 30, 2014. Language: Chinese.
  6. Title: Should Methadone Addicts Worry About Flu? Organization: National Health Research Institutes, Taiwan. February 2, 2016. Language: English.
  7. Title: Virus-mediated antibody expression attenuates methamphetamine-   induced behavioral changes in mice. Organization: 5th APSAAR & TSAS, Taiwan. May 31- Jun 3, 2017. Language: English.
  8. Title: Is it possible to treat acute lymphoblastic leukemia by combining CD19-bispecific T cell engagers and r9d2 T cells?. Organization: Department of Medical Research, Taipei Tzu Chi Hospital, Taiwan. March 17, 2022 Language: Chinese.

 

 

 
 
 
 
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