研究成果

<學術期刊論文>

  1. Tsai, C.-T.、Lin, C.-H.、Chang, C.-Y.,"Analysis of Codon Usage Bias and Base Compositional Constraints in Iridovirus",Virus Research,2007 (SCI).
  2. Chen, W.-Y、John, J. A. C.、Lin, C.-H.、Chang, C.-Y.,"Expression Pattern of Metallothionein, MTF-1 Nuclear Translocation and Its DNA-Binding Activity in Zebrafish (Danio rerio) Induced by Zinc and Cadmium.",Environmental Toxicology and Chemistry,Vol. 26,2007,pp.110-117 (SCI).
  3. Lin, C.-H.、John, J. A. C.、Lin, C.-H.、Chang, C.-Y.,"Inhibition of Nervous Necrosis Virus Propagation by Fish Mx Proteins.",Biochemical and Biophysical Research Communications,Vol. 351,2006,pp.534-539 (SCI).
  4. Cheng, C.-A.、John, J. A. C.、Wu, M.-S.、Lee, C.-Y.、Lin, C.-H.,"Characterization of Serum Immunoglobulin M of Grouper and CDNA Cloning of Its Heavy Chain.",Veterinary Immunology and Immunopathology,Vol. 109,2006,pp.255-265 (SCI).
  5. Nie, Z.、Tzeng, Y.-K.、Chang, H.-C.、Chiu, C.-C.、Chang, C.-Y.,"Microscopy-Based Mass Measurement of A Single Whole Virus in A Cylindrical Ion Trap.", Angewandte Chemie International Edition,Vol. 45,2006,pp.8131-8134(SCI).
  6. Tsai, C.-T.、Ting, J.-W.、Wu, M.-H.、Wu, M.-F.、Guo, I.-C.,"Complete Genome Sequence of the Grouper Iridovirus and Comparison of Genomic Organization with Other Iridoviruses.",Journal of Virology,Vol. 79,No. 4,2005,pp.2010-2023 (SCI).
  7. Lin, C.-H.、 John, J. A. C.、Ou, L.-W.、Chen, J.-C.、Lin, C.-H.,"Cloning and Characterization of Metallothionein Gene in Ayu Plecoglossus altivelis.",Aquatic toxicology,Vol. 66,2004,pp.111-124 (SCI).
  8. Chen, W.-Y.、John, J. A. C.、Lin, C.-H.、Lin, H.-F.、Wu, S.-C.,"Expression of Metallothionein Gene during Embryonic and Early Larval Development in Zebrafish.",Aquatic toxicology,Vol. 69,2004,pp.215-227 (SCI).
  9. Ting, J.-W.、Wu, M.-F.、Tsai, C.-T.、Lin, C.-C.、Guo, I.-C.,"Identification and Characterization of a Novel Gene of Grouper Iridovirus (GIV) Encoding a Purine Nucleoside Phosphorylase.",Vol. 85,2004,pp.2883-2892 (SCI).
  10. Lai, Y.-S.、John, J. A. C.、Lin, C.-H.、Guo, I.-C.、Chen, S.-C.,"Establishment of Cell Lines from a Tropical Grouper, Epinephelus awoara (Temminck & Schlegel), and Their Susceptibility to Grouper Irido- and Nodaviruses.",Journal of Fish Diseases,Vol. 26,2003,pp.31-42 (SCI).
  11. Herzog, W.、Zeng, X.、Lele, Z.、Sonntag, C.、Ting, J.-W.,"Adenohypophysis Formation in the Zebrafish and Its Dependence on Sonic Hedgehog.",Developmental Biology ,Vol. 254,2003,pp.36-49.
  12. Murali, S.、Wu, M.-F.、Guo, I.-C.、Chen, S.-C.、Yang, H.-W.,"Molecular Characterization and Pathogenicity of A Grouper Iridovirus (GIV) Isolated from Yellow Grouper Epinephelus awoara (Temminck & Schlegel).",Journal of Fish Diseases,Vol. 25,2002,pp.91-100 (SCI).
  13. Chiu, C.-C.、John, J. A. C.、Hseu, T.-H.、Chang, C.-Y.,"Expression of Ayu Pit-1 in Escherichia coli: Its Purification and Immunohistochemical Detection Using Monoclonal Antibody.",Protein Expression and Purification,Vol. 24,2002,pp.292-301 (SCI).
  14. Chen, W.-Y.、John, J. A. C.、Lin, C.-H.、Chang, C.-Y.,"Molecular Cloning and Developmental Expression of Zinc Finger Transcription Factor MTF-1 Gene in Zebrafish, Danio rerio.",Biochemical and Biophysical Research Communications ,Vol. 291,2002,pp.798-805 (SCI).
  15. Cheng, C.-A.、 Lu, K.-L.、Liu, E.-L.、Yang, T.-Y.、Lee, C.-Y.,"Growth Promotion of Ayu (Plecoglossus altivelis) by Gene Transfer with Rainbow Trout Growth Hormone Gene.",Zoological Studies ,Vol. 41,No. 3,2002,pp.303-310(SCI).
  16. Chang, C.-C.、Tsai, C.-T.、Chang, C.-Y.,"Structural Restoration of Inactive Recombinant Fish Growth Hormones by Chemical Chaperonin and Solvent Restraint Approaches. ",Vol. 15,2002,pp.437-441 (SCI).
  17. Lai, Y.-S.、John, J. A. C.、Guo, I.-C.、Chen, S.-C.、Fang, K.,"In Vitro Efficiency of Intra- and Extracellular Immunization with Mouse Anti-YGNNV Antibody against Yellow Grouper Nervous Necrosis Virus.",Vaccine,Vol. 20,2002,pp.3221-3229 (SCI).
  18. Chiu, C.-C.、Ting, J.-W.、Hseu, T.-H.、Chang, C.-Y.,"Characterization of Transactivation Domain and Developmental Expression of Pituitary Specific Transcription Factor, Pit-1 of Ayu (Plecoglossus altivelis).",General and Comparative Endocrinology,Vol. 127,2002,pp.307-313 (SCI).

<學術會議論文>

  1. Lin, C.H.、John, J.A.C.、Lin, C.H.、Chang, C.Y.,"Molecular Cloning and Tissue-specific Expression of Mx Multi-forms from Grouper.",VNN 2006,Hiroshima,Japan,November 2006,pp.N/A.
  2. Lin, C.H.、John, J.A.C.、Lin, C.H.、Chang, C.Y.,"Inhibition of NervousNecrosis Virus Propagation by Grouper Mx Proteins.",VNN 2006,Hiroshima,Japan ,November 2006,pp.N/A.
  3. Chang, C. Y.、Chen, W. Y.、John, J. A. C.,"Excess Heavy Metal Affects Zebrafish Embryo Development Indicated by Metallothionein Express.",AQUA 2006,Florence,Italy,May 2006,pp.N/A.
  4. Yeh C. H.、Wu, M, H.、Wu, J. C.、Chang, C. Y.,"Study of Mouse Monoclonal Immunoprophylaxis against Fish Nervous Necrosis Virus",AQUA 2006,Florence,Italy,May 2006,pp.N/A.
  5. Chang, C.Y.、John, J.A.C.、Wu M.S.、Lee C.Y.、Lin C.H.,"Characterization of serum immunoglobulin M of grouper and cDNA cloning of its heavy chain.",12th International European Association of Fish Pathologists Conference on Fish Diseases,Copenhagen,Denmark,September 2005,pp.N/A.
  6. Yeh, C.H.、Kung, C.W.、Lin, P.W.、Lee J.C.、Chen, M.J.,"Isolation and Characterization of a Koi Herpesvirus in Common Carp from Taiwan.",12th International European Association of Fish Pathologists Conference on Fish Diseases,Copenhagen,Denmark,September 2005,pp.N/A.
  7. Tsai, C.-T.、Ting, J.-W.、Wu, M.-H.、Wu, M.-F.、Guo, I.-C.,"Complete Genome Sequence of the Grouper Iridovirus and Comparison of Genomic Organization with Other Iridoviruses.",The 6th International Symposium on Viruses of Lower Vertebrates,Hakodate, Hokkaido,Japan,September 2004,pp.N/A.
  8. Chang, C.-Y.、Tsai, C.-T.、John, J.A.C.,"Use of iridovirus common genes to construct a consensus iridovirus phylogenetic tree",The 6th International Symposium on Viruses of Lower Vertebrates,Hakodate, Hokkaido,Japan,September 2004,pp.N/A.

<專書>

  1. ,"Fish Genetics and Aquaculture Biotechnology",Oxford & IBH Publishing Co. Pvt. Ltd. New Delhi,2005.

<國科會研究>

  1. 張繼堯,「石斑魚虹彩病毒細胞凋亡相關基因之研究」,2006年8月,NSC 95-2311-B-001-069-MY3。
  2. 張繼堯,「石斑魚健康魚苗之培育」,2006年5月,NSC 95-2622-B-001-001-CC3。
  3. 張繼堯,「石斑魚無特定病原菌優質種苗之開發」,2005年8月 至 2006年12月,NSC 94-2317-B-001-015-。
  4. 張繼堯,「斑馬魚第一型金屬應答轉錄因子基因發育期之表現與調控(3/3) 」,2005年8月 至 2006年7月,NSC 94-2311-B-001-018-。
  5. 張繼堯,「神經壞死病毒與虹彩病毒疫苗枝研發與應用(Ⅲ)」,2005年7月 至 2006年6月,NSC 94-2317-B-001-007-。
  6. 張繼堯,「斑馬魚第一型金屬應答轉錄因子基因發育期之表現與調控(2/3) 」,2004年8月 至 2005年7月,NSC 93-2311-B-001-032-。
  7. 張繼堯,「神經壞死病毒及虹彩病毒疫苗之研發與應用(II)」,2004年7月 至 2005年6月,NSC 93-2317-B-001-011-。

<非國科會研究>

  1. 張繼堯,「虹彩病毒分子檢測技術與試劑開發」,,2006年1月 至 2006年12月。
  2. 張繼堯,「石斑魚虹彩病毒次單位疫苗之研發」,,2005年1月 至 2005年12月。
  3. 張繼堯,「魚類抗神經壞死病毒之小鼠單株抗體基因預防法」,,2004年1月 至 2004年12月。
  4. 張繼堯,「石斑魚與病毒交互作用之功能性基因體研究(2/2)」,,2004年1月 至 2004年12月。

<專利>

  1. 張繼堯 ,魚類神經壞死病毒及石斑魚虹彩病毒檢測試劑之開發,編號:中研院技轉合約10T-930506-1N,2005.0820。
  2. 張繼堯 、丁靜雯、呂昆霖、林志鴻、張家靖,蔡志東,Fish growth hormones,編號:美國 6429305,2001。

<國際會議補助>

  1. 張繼堯,「VNN 2006」,NA,2006.11.28。
  2. 張繼堯,「AQUA 2006」,NA,2006.05.09。
  3. 張繼堯,「12th International European Association of Fish Pathologists Conference on Fish Diseases」,NA,2005.09.11。
  4. 張繼堯,「The 6th International Symposium on Viruses of Lower Vertebrates」,NA,2004.09.19。