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辜惠君老師
辜惠君老師
研究概況:
天然物開發
人類疾病之實驗動物模式
人類誘導性多功能幹細胞培養
研究方向:
探討天然物成份與其衍生物活性並應用於新藥研發
探討特定基因在人類疾病中的訊息傳遞路徑
研究計畫
- 「探討肺纖維化之新型治療策略」,補助單位: 科技部。執行期限:2020/08/01 - 2023/07/31。
- 「探討DPP4基因在心臟重塑扮演的角色」,補助單位: 科技部。執行期限:2017/08/01 - 2020/07/31。
期刊論文
- Lee SY, Wu ST, Liang YJ, Su MJ, Huang CW, Jao YH, 辜惠君*. Soluble Dipeptidyl Peptidase-4 Induces Fibroblast Activation Through Proteinase-Activated Receptor-2. Front Pharmacol. 2020 Sep 30;11:552818.
- Lee SY, Hsin LW, Su MJ, ChangChien CC, 辜惠君*. A Novel Isoquinoline Derivative Exhibits Anti-inflammatory Properties and Improves the Outcomes of Endotoxemia. Pharma Reports. 2019 Dec 1;71(6):1281-1288.
- Lee SY, Hung ST, Wang KT, 辜惠君*. Coronary Artery Fistula Presented as a Mediastinal Mass. J Formos Med Assoc. 2019 Aug;118(8):1268-1269.
- Lee SY, Wu CW, Chang WH, 辜惠君*. Fever and jaundice caused by hemophagocytic syndrome. J Formos Med Assoc. 2019 Feb;118(2):649-650.
- 辜惠君, Liang YJ*. Incretin-based therapy for diabetic ulcers: from bench to bedside. Expert Opin Investig Drugs. 2018 Dec;27(12):989-996.
- 辜惠君, Lee SY, Wu YK, Yang KC, Su MJ*. A Model of Cardiac Remodeling through Constriction of the Abdominal Aorta in Rats. J Vis Exp. 2016 Dec 2;(118).
- 辜惠君, Lee SY, Lee SS, Su MJ* Thaliporphine, an alkaloid from Neolitsea Konishii, exerts antioxidant, anti-inflammatory, and anti-apoptotic responses in guinea pig during cardiovascular collapse in inflammatory disease. Journal of Functional Food. 2016 July 26; 57-64.
- 辜惠君, Lee SY, Kuo YH*, Yang KC, Su MJ*; Modification of Caffeic Acid with Pyrrolidine Enhances Anti-oxidant Ability by Activating AKT-HO-1 Pathway. PLoS One. 2016 Feb 11(2): e0148545.
- Lee SY, 辜惠君, Kuo YH, Yang KC, Chiu HL, Su MJ*; Caffeic Acid Ethanolamide Prevents Cardiac Dysfunction by Cardiac Bioenergetic Preservation through Sirtuin Dependent Pathway. Journal of Biomedical Science. 2015 Sep 22: 80.
- Lee SY*, Chen CH, Huang GC, 辜惠君, Shih SC, Hung LC, Sun FJ, Hsu CP, Ho YH, Tai JH, Lai YL, Chang WH*; Factors associated with attitude and knowledge toward hospice palliative care among medical caregivers. International Journal of Gerontology. 2015 Jun 9; 98-102.
- 辜惠君, Lee SY, Chen CH, Wang YH, Lin CT, Lee SS, Li TH, Su MJ*; TM-1-1DP exerts protective effect against myocardial ischemia reperfusion injury via AKT-eNOS pathway. Naunyn-Schmiedebergs Archives of Pharmacology. 2015 May 388(5):539-48.
- Lee SY, 辜惠君, Kuo YH, Chiu HL, Su MJ*; Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways. Journal of Biomedical Science. 2015 Mar 22: 18.
- 辜惠君, Su MJ*; DPP4 deficiency preserved cardiac function in abdominal aortic banding rats. PLoS One, 2014 Jan 9(1):e85634.
- 辜惠君, Chen WP, Su MJ*; DPP4 deficiency exerts protective effect against H2O2 induced oxidative stress in isolated cardiomyocytes. PLoS One. 2013 Jan 8(1):e54518.
- 辜惠君, Chen WP, Su MJ*; DPP4 deficiency preserves cardiac function via GLP-1 signaling in rats subjected to myocardial ischemia/ reperfusion. Naunyn-Schmiedebergs Archives of Pharmacology. 2011 Aug 384(2):197-207.
- 辜惠君, Chen WP, Su MJ*. GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):463-74.
- Chen WP, Tzeng HJ, 辜惠君, Ho YJ, Lee SS, Su MJ*.Thaliporphine ameliorates cardiac depression in endotoxemic rats through attenuating TLR4 signaling in the downstream of TAK-1 phosphorylation and NF-κB signaling. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):441-53.